Details

Autor(en) / Beteiligte

• Ma, Liang
• Fan, Fei
• Shi, Weinan
• Ji, Yunyun
• Wang, Xianghui
• Chang, Shengjiang

Titel

Terahertz on-chip sensor based on Mach-Zehnder waveguide interferometer for selective recognition of reducing drug

Ist Teil von

• Sensors and actuators. A. Physical., 2024-05, Vol.370, Article 115282

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• The selective detection of biochemical substances with high sensitivity in the terahertz (THz) band has emerged as a prominent research area, attracting significant attention. Waveguide-on-chip detection of biochemical substances can effectively enhance the interaction between samples and waves, but there is a lack of reports in the THz band. In this work, a dual-channel metallic parallel-plate waveguide (PPWG) is applied to creatively construct a THz Mach-Zehnder interferometer (MZI) sensor for highly sensitive and selective detection of reducing drug on a chip. This sensor exhibits a strong numerical response of 0.75 THz/RIU, allowing for dynamic sensitivity adjustment through mechanically tuning structural parameters, and it is modified through in-situ growth of Prussian blue (PB) to achieve the selective detection of reducing drug. The experiments confirm that the designed sensor-on-chip possesses exceptional detection sensitivity for cysteamine, reaching an impressive maximum sensitivity of 0.09 GHz/nmol and a low limit of detection of 88 nmol. The modified chip exhibits selective detection of cysteamine, demonstrating a maximum response difference of 4.2 times compared to other configurations. Collectively, a pioneer validates the feasibility of the highly sensitive MZI chip in the THz regime and opens up new possibilities for advancing THz biochemical sensing. [Display omitted] •The Mach-Zehnder interferometer sensor is creatively constructed in the THz regime.•The THz Mach-Zehnder interferometer sensor possesses high sensitivity and selectiveness.•The sensitivity allows for flexible control by mechanical adjustment of structural parameters.•The functional modification of the sensor is carried out using Prussian blue in-situ growth.•Selective recognition of reducing drugs can be achieved.