Details

Autor(en) / Beteiligte

• Zhou, Jiena
• Jin, Lanfei
• Zhou, Yexinyi
• Zhong, Kunhong
• Huang, Kegui
• Zhang, Qi
• Tang, Jun
• Zhang, Xue
• Peng, Lihe
• Li, Shuai
• Lv, Na
• Yu, Dongdong
• Zhu, Qinheng
• Guo, Jing
• Luo, Qiong
• Chen, Guangdi

Titel

Associations of multiple metals exposure with immunoglobulin levels in pregnant women: Hangzhou Birth Cohort Study

Ist Teil von

• Journal of environmental sciences (China), 2025-05, Vol.151, p.560-572

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2025

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •Associations of exposure to multiple metals with immunoglobulin levels were examined for pregnancy.•We used quantile-based g-computation, and Bayesian kernel machine regression to explore the effect of metal mixtures on Igs.•Blood Mn level was positively linked to immunoglobulin A, immunoglobulin G, and immunoglobulin M level.•Blood As level was negatively associated with immunoglobulin E levels. Metal may affect maternal immune function, but few epidemiological studies have reported the associations between multiple-metal exposure and maternal immunoglobulin (Ig) levels. Based on the Hangzhou Birth Cohort Study, 1059 participants were included, and eleven metals in whole blood samples and serum IgA, IgG, IgE and IgM levels were measured. Linear regression, quantile-based g-computation (QGC), and Bayesian kernel machine regression (BKMR) models were used to evaluate the associations. Compared with the first tertile of metal levels, arsenic (As) was negatively associated with IgE (β = -0.25, 95% confidence interval (CI) = -0.48 to -0.02). Moreover, significant associations of manganese (Mn) with IgA, IgG and IgM were demonstrated (β = 0.10, 95% CI = 0.04 to 0.18; β = 0.07, 95% CI = 0.03 to 0.12; β = 0.10, 95% CI = 0.03 to 0.18, respectively). Cadmium (Cd) were associated with higher levels of IgM. QGC models showed the positive association of the metal mixtures with IgA and IgG, with Mn playing a major role. Mn and Cd had positive contributions to IgM, while As had negative contributions to IgE. In the BKMR models, the latent continuous outcomes of IgA and IgG showed a significant increase when all the metals were at their 60th percentile or above compared to those at their 50th percentile. Therefore, exposure to metals was associated with maternal Igs, and mainly showed that Mn was associated with increased levels of IgA, IgG and IgM, and As was associated with low IgE levels. [Display omitted]