Details

Autor(en) / Beteiligte

• Laurini, Erik
• Zampieri, Daniele
• Mamolo, Maria Grazia
• Vio, Luciano
• Zanette, Caterina
• Florio, Chiara
• Posocco, Paola
• Fermeglia, Maurizio
• Pricl, Sabrina

Titel

A 3D-pharmacophore model for σ 2 receptors based on a series of substituted benzo[d]oxazol-2(3 H)-one derivatives

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2010, Vol.20 (9), p.2954-2957

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2010

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• In this work we developed a 3D-pharmacophore model for σ 2 receptor based on 19 benzooxazolone derivatives. The best 3D-pharmacophore hypothesis, consisting of five features: a positive ionizable, a hydrogen bond acceptor, a hydrophobic aromatic, a hydrophobic aliphatic, and a generic hydrophobic provided a 3D-QSAR model with a correlation coefficient of 0.97 and a RMSD of 0.48.