Details

Autor(en) / Beteiligte

• Letavic, Michael A.
• Keith, John M.
• Jablonowski, Jill A.
• Stocking, Emily M.
• Gomez, Leslie A.
• Ly, Kiev S.
• Miller, Jennifer M.
• Barbier, Ann J.
• Bonaventure, Pascal
• Boggs, Jamin D.
• Wilson, Sandy J.
• Miller, Kirsten L.
• Lord, Brian
• McAllister, Heather M.
• Tognarelli, D.J.
• Wu, Jiejun
• Abad, Marta C.
• Schubert, Carsten
• Lovenberg, Timothy W.
• Carruthers, Nicholas I.

Titel

Novel tetrahydroisoquinolines are histamine H 3 antagonists and serotonin reuptake inhibitors

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.1047-1051

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Novel histamine H 3 antagonists with serotonin reuptake activity are reported. A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H 3 ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these novel compounds are discussed.