Details

Autor(en) / Beteiligte

• Jonas, Rebecca
• Patel, Toral
• Crabtree, Tami R.
• Jennings, Robert S.
• Heo, Ran
• Park, Hyung-Bok
• Marques, Hugo
• Chang, Hyuk-Jae
• Stuijfzand, Wijnand J.
• van Rosendael, Alexander R.
• Choi, Jung Hyun
• Doh, Joon-Hyung
• Her, Ae-Young
• Koo, Bon-Kwon
• Nam, Chang-Wook
• Shin, Sang-Hoon
• Cole, Jason
• Gimelli, Alessia
• Khan, Muhammad Akram
• Lu, Bin
• Gao, Yang
• Nabi, Faisal
• Al-Mallah, Mouaz H.
• Nakazato, Ryo
• Schoepf, U. Joseph
• Driessen, Roel S.
• Bom, Michiel J.
• Thompson, Randall C.
• Jang, James J.
• Ridner, Michael
• Rowan, Chris
• Avelar, Erick
• Généreux, Philippe
• Knaapen, Paul
• de Waard, Guus A.
• Pontone, Gianluca
• Andreini, Daniele
• Bax, Jeroen J.
• Choi, Andrew D.
• Earls, James P.
• Hoffmann, Udo
• Min, James K.
• Villines, Todd C.

Titel

Relationship Of Sex To Atherosclerotic Plaque Characteristics By Differing Angiographic Stenosis Severity

Ist Teil von

• The American journal of cardiology

Ort / Verlag

Elsevier Inc

Link zum Volltext

Beschreibungen/Notizen

• It is unknown whether sex influences the atherosclerotic plaque characteristics (APCs) of lesions of varying angiographic stenosis severity. This study evaluated the imaging data of 303 symptomatic patients from the derivation arm of the CREDENCE trial, all of whom underwent coronary computed tomographic angiography (CCTA) and clinically indicated non-emergent invasive coronary angiography upon study enrollment. Index tests were interpreted by two blinded core laboratories, one of which performed quantitative CCTA using an AI application to characterize and quantify APCs, including percent atheroma volume (PAV), low density non-calcified plaque (LD-NCP), noncalcified plaque (NCP), calcified plaque (CP), lesion length, positive arterial remodeling, and high-risk plaque (a combination of LD-NCP and positive remodeling ≥1.10); the other classified lesions as obstructive (≥50% diameter stenosis) or non-obstructive (<50% diameter stenosis) based on quantitative invasive coronary angiography. The relationship between APCs and angiographic stenosis was further examined by sex. The mean age of the study cohort was 64.4±10.2 years (29.0% female). Among patients with obstructive disease, men had more LD-NCP PAV (0.5±0.4 v. 0.3±0.8; p=0.03) and women had more CP PAV (11.7±1.6 v. 8.0±0.8; p=0.04). Obstructive lesions had more NCP PAV compared to their non-obstructive lesions in both sexes, however, obstructive lesions in women also demonstrated greater LD-NCP PAV (0.4±0.5 v. 1.0±1.8; p=0.03), and CP PAV (17.4±16.5 v. 25.9±18.7; p=0.03) than non-obstructive lesions. Comparing the composition of obstructive lesions by sex, women had more CP PAV (26.3±3.4 v. 15.8±1.5; p=0.005) while men had more NCP PAV (33.0±1.6 v. 26.7±2.5; p=0.04). Men had more LD-NCP PAV in non-obstructive lesions compared to women (1.2±0.2 v. 0.6±0.2; p=0.02). In conclusion, there are sex specific differences in plaque composition based on stenosis severity.