Details

Autor(en) / Beteiligte

• Curtis, Neil R.
• Kulagowski, Janusz J.
• Leeson, Paul D.
• Ridgill, Mark P.
• Emms, Frances
• Freedman, Stephen B.
• Patel, Shil
• Patel, Smita

Titel

Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D 4 ligands

Ist Teil von

• Bioorganic & medicinal chemistry letters, 1999-02, Vol.9 (4), p.585-588

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

1999

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• 7-azaindole compounds bearing a cyclic amine moiety linked by a one or two carbon chain attached at the 2- or 3-position were synthesised and evaluated as potential dopamine D 4 ligands. Highest affinity and selectivity for the D 4 receptor resided in the 3-aminomethyl-7-azaindole series. 7-azaindole compounds bearing a cyclic amine moiety linked by a one or two carbon chain (n = 1 or 2) attached at the 2- or 3-position were synthesised and evaluated as potential dopamine D 4 ligands. Highest affinity and selectivity for the D 4 receptor resided in the 3-aminomethyl-7-azaindole series (exemplified by L-745,870).