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Synthesis, magnetic properties, surface modification and cytotoxicity evaluation of Y 3Fe 5− xAl xO 12 (0⩽ x⩽2) garnet submicron particles for biomedical applications
Ist Teil von
Journal of magnetism and magnetic materials, 2001, Vol.234 (3), p.409-418
Ort / Verlag
Elsevier B.V
Erscheinungsjahr
2001
Quelle
Access via ScienceDirect (Elsevier)
Beschreibungen/Notizen
Yttrium aluminum iron garnet Y
3Fe
5−
x
Al
x
O
12 compounds were produced by the citrate gel process by varying the aluminum content
x from 0 to 2. Particles with an average size of about 100
nm and a specific surface area ranging from 6 to 28
m
2/g were obtained. Curie temperatures (
T
C) were determined from the temperature dependence of the field-cooled magnetization (FCM) and the remnant magnetization (REM) and range from –40°C to 280°C. According to the magnetic moment variation, the aluminum cation seems to replace the iron cation in the tetrahedral site for compounds with
x<0.7. 3-Aminopropyltrimethoxysilane (γ-APS) was grafted onto the particles surface and its presence confirmed by infra-red spectroscopy. Cytotoxicity assays were carried out during a period of 13 days using human microglia and rat glioblastoma cell lines. The presence of the amine-functionalized particles did not affect the cell viability or the culture growth rate. Finally, amine-functionalized particles were successfully labeled with covalently linked fluorescing molecules.