Details

Autor(en) / Beteiligte

• Cha, Lide
• Tang, Yijie
• Guo, Yisong
• Chang, Wei-Chen

Titel

Olefin, Nitrile and Isonitrile Installation Catalyzed by Metalloenzymes

Ist Teil von

• Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, 2013

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2013

Link zum Volltext

Beschreibungen/Notizen

• Olefin, nitrile and isonitrile moieties are commonly found in nature and various approaches have been developed to install these functional groups. In this article, we summarize recent discoveries and the corresponding mechanisms of metallo-enzymes catalyzed CC, CN and NC installation. Among them, different metallo-cofactors, such as non-heme iron, P-450, di-iron, and radical SAM, with various reactive species, such as Fe(IV)-oxo, Compound I, and 5′-deoxyadenosyl radical, are utilized to trigger the designated reactions.