Details

Autor(en) / Beteiligte

• Speck, Nancy
• Peeters, Marian
• Dzierzak, Elaine

Titel

10 - Development of the Vertebrate Hematopoietic System

Ist Teil von

• Mouse Development, 2002, p.191-210

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2002

Link zum Volltext

Quelle

ScienceDirect eBooks

Beschreibungen/Notizen

• The adult hematopoietic system is a heterogeneous group of fully differentiated blood cells and their precursors. At its foundation are hematopoietic stem cells (HSCs) from which terminally differentiated blood cells are continuously renewed. The HSCs divide to yield immature progenitors, which in turn progress through many intermediate stages of commitment in a cascade of differentiation events. The large number of intermediate cell types and the fact that blood cells circulate throughout the embryo present many challenges to studying the embryonic origins and generation of the adult hematopoietic system. The knowledge of embryonic hematopoiesis is drawn from studies in both mammalian and nonmammalian vertebrates. The ability to perform fate mapping experiments, particularly in avian and amphibian embryos, contributes substantially to understand the mesodermal origins of hernatopoietic cells beginning at gastrulation, and has firmly established that multiple independent origins of hematopoiesis occur in the developing embryo. Hematopoiesis in vertebrates originates in multiple anatomically distinct sites in the embryo, including the yolk sac, the vitelline and umbilical arteries, and in the intraembryonic region.