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Effect of Ca 2+ deprivation on short-term desensitization of isolated smooth muscle cells showing an all-or-none response to acetylcholine
Ist Teil von
General pharmacology, 1988, Vol.19 (3), p.441-445
Ort / Verlag
Elsevier Inc
Erscheinungsjahr
1988
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
1.
1. Short-term desensitization of the contractile response of isolated smooth muscle cells from guinea pig taenia caecum to acetylcholine was examined in the absence of external Ca
2+.
2.
2. Isolated smooth muscle cells contracted to 10
−7−10
−6 M acetylcholine, showing an all-or-none response.
3.
3. Desensitization was induced by incubating the cells with 10
−4 M acetylcholine for 10 min in Ca
2+-free solution.
4.
4. Desensitized cells showed an all-or-none response but required a higher concentration of acetylcholine for induction of contraction, indicating that the desensitization was due to a change in the threshold concentration.
5.
5. Desensitization is suggested to be induced before massive influx of Ca
2+ into the cells.