Details

Autor(en) / Beteiligte

• Moreno-Ocio, Iñigo
• Aquilino, Mónica
• Llorente, Lola
• Martínez-Madrid, Maite
• Rodríguez, Pilar
• Méndez-Fernández, Leire
• Planelló, Rosario

Titel

Toxicogenomics of the Freshwater Oligochaete, Tubifex tubifex ( Annelida , Clitellata ), in Acute Water-Only Exposure to Arsenic

Ist Teil von

• International journal of molecular sciences, 2024-03, Vol.25 (6), p.3382

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Electronic Journals Library - Freely accessible e-journals

Beschreibungen/Notizen

• A toxicogenomic approach was used for toxicity evaluation of arsenic in the aquatic environment, and differential gene expression was investigated from 24 h and 96 h water-only acute toxicity tests with the aquatic oligochaete, ( , ). Several toxicological endpoints (survival and autotomy) of the oligochaete and tissue residues were measured, and dose-response modelling of gene expression data was studied. A reference transcriptome of the aquatic oligochaete, , was reconstructed for the first time, and genes related to cell stress response ( , , , and ), energy metabolism ( ), oxidative stress ( , , and ), and the genes involved in the homeostasis of organisms ( , , and ) were identified and characterised. The potential use of the genes identified for risk assessment in freshwater ecosystems as early biomarkers of arsenic toxicity is discussed.