Details

Autor(en) / Beteiligte

• Chen, Song
• Shi, Xuetao
• Morita, Hiromi
• Li, Jie
• Ogawa, Nobuhiro
• Ikoma, Toshiyuki
• Hayakawa, Satoshi
• Shirosaki, Yuki
• Osaka, Akiyoshi
• Hanagata, Nobutaka

Titel

BMP-2-loaded silica nanotube fibrous meshes for bone generation

Ist Teil von

• Science and technology of advanced materials, 2011-12, Vol.12 (6), p.065003

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2011

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.