Details

Autor(en) / Beteiligte

• Kim, Hayeong
• Gil Kang, Choon
• Seong, Hur
• Kim, Taeyoon
• Jo, Jaehyoek
• Kim, Gha-hyun J.
• Wook Kim, Seung
• Kim, Doman

Titel

Enhancement of the water solubility of curcuminoids by micelle formulations with ginsenosides to improve antioxidant activity, suppress nitric oxide release, and reduce lipid accumulation

Ist Teil von

• Journal of functional foods, 2024-05, Vol.116, p.106186, Article 106186

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2024

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• [Display omitted] •Ginsenosides from P. ginseng enhanced water-soluble curcuminoids up to 2,450 µg/mL.•Antioxidant activity of ginsenosides were improved by micelle formulation with curcuminoids.•GS-CUR exerted synergistic effects, suppressing NO and lipid accumulation in cells. This study explores the formulation of self-micelle ginsenoside saponins from Panax ginseng with curcuminoids from turmeric. Although ginsenosides are hydrophilic and poorly membrane-permeable, they increase the solubility and absorption of insoluble compounds such as curcuminoids. The optimized ginsenoside-curcuminoid (GS-CUR) formulation achieved a water solubility of 2,450 µg/mL using Response Surface Methodology (RSM) at 42.9 % (v/v) water in ethanol, 389.7 mg/mL ginsenosides, and 9.06 mg/mL curcuminoids. Analytical techniques such as SEM, X-ray diffraction, and FTIR spectroscopy confirmed the presence of curcuminoids in GS-CUR. The GS-CUR complex exhibited enhanced antioxidant activities compared to free curcuminoids. Moreover, GS-CUR suppressed the release of nitric oxide in lipopolysaccharide-stimulated RAW264.7 cells by 3.77-fold and reduced lipid accumulation in 3 T3-L1 cells by 13.2-fold more than free curcuminoids. These findings suggest GS-CUR's potential as a functional material in the pharmaceutical, cosmetic, and food industries.