Details

Autor(en) / Beteiligte

• Biavatti, Maique W.
• Vieira, Paulo C.
• Silva, M. Fátima das G. F. da
• Fernandes, João B.
• Victor, Sandra R.
• Pagnocca, Fernando C.
• Albuquerque, Sérgio
• Caracelli, Ignez
• Zukerman-Schpector, Julio

Titel

Biological Activity of Quinoline Alkaloids from Raulinoa echinata and X-ray Structure of Flindersiamine

Ist Teil von

• Journal of the Brazilian Chemical Society, 2002-02, Vol.13 (1), p.66-70

Ort / Verlag

Sociedade Brasileira de Química

Erscheinungsjahr

2002

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Phytochemical survey of stems and leaves extracts of the South Brazilian endemic plant Raulinoa echinata Cowan, Rutaceae, led to the isolation of known furoquinoline alkaloids: the widespread skimmianine; kokusaginine, maculine, flindersiamine, and also quinolone derivatives: 1-methyl-2-n-nonyl-4-quinolone, 2-n-nonyl-4-quinolone and 1-methyl-2-phenyl-4-quinolone. These alkaloids showed antifungal activity against Leucoagaricus gongylophorus; the symbiotic fungus of leaf-cutting ants (Atta sexdens). They were inactive or displayed weak inhibitory activity when assayed in vitro against trypomastigote forms of Trypanosoma cruzi. In this paper, the isolation, structure elucidation and bioactivity results of these compounds are reported together with the X-ray structure of flindersiamine.