Details

Autor(en) / Beteiligte

• Neupane, Sanjiv
• Aryal, Yam Prasad
• Kim, Tae-Young
• Yeon, Chang-Yeol
• An, Chang-Hyeon
• Kim, Ji-Youn
• Yamamoto, Hitoshi
• Lee, Youngkyun
• Sohn, Wern-Joo
• Kim, Jae-Young

Titel

Signaling Modulations of miR-206-3p in Tooth Morphogenesis

Ist Teil von

• International journal of molecular sciences, 2020-07, Vol.21 (15), p.5251

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs that post-transcriptionally regulate gene expression in organisms. Most mammalian miRNAs influence biological processes, including developmental changes, tissue morphogenesis and the maintenance of tissue identity, cell growth, differentiation, apoptosis, and metabolism. The has been correlated with cancer; however, developmental roles of this miRNA are unclear. In this study, we examined the expression pattern and evaluated the developmental regulation of during tooth morphogenesis using ex-vivo culture method. The expression pattern of was examined in the epithelium and mesenchyme of developing tooth germ with stage-specific manners. Perturbation of the expression of clearly altered expression patterns of dental-development-related signaling molecules, including and . The gene expression complemented with change in cellular events including, apoptosis and proliferation which caused altered crown and pulp morphogenesis in renal-capsule-calcified teeth. Especially, mislocalization of β-Catenin and SMAD1/5/8 were observed alongside dramatic alterations in the expression patterns of and . Overall, our data suggest that the regulate the cellular physiology during tooth morphogenesis through modulation of the Wnt, Bmp, Fgf, and Shh signaling pathways to form proper tooth pulp and crown.