Details

Autor(en) / Beteiligte

• Daoudi, Hadjer
• Plesník, Jiří
• Sayed, Amira
• Šerý, Omar
• Rouabah, Abdelkader
• Rouabah, Leila
• Khan, Naim Akhtar

Titel

Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers

Ist Teil von

• Nutrients, 2015-11, Vol.7 (11), p.9096-9104

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2015

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Growing number of evidences have suggested that oral fat sensing, mediated by a glycoprotein CD36 (cluster of differentiation 36), plays a significant role in the development of obesity. Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake. In the present study, we examined whether an increase in body mass index (BMI) is associated with altered oleic acid lingual detection thresholds and blood lipid profile in young Algerian teenagers (n = 165). The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001). We also studied the association between rs1761667 polymorphism of CD36 gene and obesity. The AA and AG genotypes were more frequent in obese teenagers, whereas GG genotype was more common in lean participants. The A-allele frequency was higher in obese teenagers than that in lean children. We report that rs1761667 polymorphism of CD36 gene and oro-gustatory thresholds for fat might play a significant role in the development of obesity in young teenagers.