Details

Autor(en) / Beteiligte

• Singer, Mervyn
• Young, Paul J
• Laffey, John G
• Asfar, Pierre
• Taccone, Fabio Silvio
• Skrifvars, Markus B
• Meyhoff, Christian S
• Radermacher, Peter

Titel

Dangers of hyperoxia

Ist Teil von

• Critical care (London, England), 2021-12, Vol.25 (1), p.440-15, Article 440

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Oxygen (O ) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS). Supplemental O , i.e. inspiratory O concentrations (F O ) > 0.21 may cause hyperoxaemia (i.e. arterial (a) PO  > 100 mmHg) and, subsequently, hyperoxia (increased tissue O concentration), thereby enhancing ROS formation. Here, we review the pathophysiology of O toxicity and the potential harms of supplemental O in various ICU conditions. The current evidence base suggests that PaO  > 300 mmHg (40 kPa) should be avoided, but it remains uncertain whether there is an "optimal level" which may vary for given clinical conditions. Since even moderately supra-physiological PaO may be associated with deleterious side effects, it seems advisable at present to titrate O to maintain PaO within the normal range, avoiding both hypoxaemia and excess hyperoxaemia.