Details

Autor(en) / Beteiligte

• Zoungbédji, David Mahouton
• Padonou, Germain Gil
• Sovi, Arthur
• Konkon, Alphonse Keller
• Salako, Albert Sourou
• Azondékon, Roseric
• Sidick, Aboubakar
• Ahouandjinou, Juvénal Minassou
• Towakinou, Linda
• Ossè, Razaki
• Aïkpon, Rock
• Affoukou, Cyriaque
• Baba-Moussa, Lamine
• Akogbéto, Martin

Titel

Bio-efficacy of Olyset ® Plus, PermaNet ® 3.0 and Interceptor ® G2 on pyrethroid-resistant populations of Anopheles gambiae s.l. prior to the June 2023 net distribution campaign in Benin, West Africa

Ist Teil von

• Tropical medicine and health, 2024-04, Vol.52 (1), p.34-34, Article 34

Ort / Verlag

Japan: BioMed Central

Erscheinungsjahr

2024

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• This study investigates the effectiveness of new-generation mosquito nets, like Olyset Plus and PermaNet 3.0, and dual-action nets such as Interceptor G2, against pyrethroid-resistant Anopheles gambiae mosquitoes following the 2023 mass distribution of long-lasting insecticidal nets in Benin. We tested wild mosquito populations from six communes in Benin against various pyrethroid (permethrin 0.75%, alphacypermethrin 0.05%, and deltamethrin 0.05%) using WHO tube tests. Additionally, we exposed mosquitoes to chlorfenapyr 100 µg/ml using the CDC bottle bioassay method. A subset of mosquitoes underwent biochemical and PCR tests to check the overexpression of metabolic enzymes and the Kdr L1014F mutation. We evaluated the effectiveness of Olyset Plus, PermaNet 3.0, and Interceptor G2 nets using cone and tunnel tests on both laboratory and field populations of An. gambiae. Overall, the highest mortality rate was 60% with pyrethroid and 98 to100% with chlorfenapyr. In cone tests, all three types of nets induced mortality rates above 80% in the susceptible laboratory strain of An. gambiae. Notably, Olyset Plus showed the highest mortality rates for pyrethroid-resistant mosquitoes in cone tests, ranging from 81.03% (95% CI: 68.59-90.13) in Djougou to 96.08% (95% CI: 86.54-99.52) in Akpro-Missérété. PermaNet 3.0 had variable rates, from 42.5% (95% CI: 27.04-59.11) in Djougou to 58.54% (95% CI: 42.11-73.68) in Porto-Novo. However, revealed good results for Interceptor G2, with 94% (95% CI: 87.40-97.77) mortality and 89.09% blood sampling inhibition in local populations of An. gambiae. In comparison, Interceptor had lower rates of 17% (95% CI: 10.23-25.82) and 60%, respectively. These results suggest that tunnel tests are effective for evaluating dual-active ingredient nets. Additionally, Interceptor G2 and PBO nets like Olyset Plus could be considered as alternatives against pyrethroid-resistant mosquitoes.