BMC pulmonary medicine, 2020-07, Vol.20 (1), p.203-6, Article 203
2020
Details
- Autor(en) / Beteiligte
- Titel
- SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospital
- Ist Teil von
- BMC pulmonary medicine, 2020-07, Vol.20 (1), p.203-6, Article 203
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- SpringerLink
- Beschreibungen/Notizen
- COVID-19 is an infectious disease caused by a novel coronavirus (SARS-CoV-2). The immunopathogenesis of the infection is currently unknown. Healthcare workers (HCWs) are at highest risk of infection and disease. Aim of the study was to assess the sero-prevalence of SARS-CoV-2 in an Italian cohort of HCWs exposed to COVID-19 patients. A point-of-care lateral flow immunoassay (BioMedomics IgM-IgG Combined Antibody Rapid Test) was adopted to assess the prevalence of IgG and IgM against SARS-CoV-2. It was ethically approved ("Milano Area 1" Ethical Committee prot. n. 2020/ST/057). A total of 202 individuals (median age 45 years; 34.7% males) were retrospectively recruited in an Italian hospital (Milan, Italy). The percentage (95% CI) of recruited individuals with IgM and IgG were 14.4% (9.6-19.2%) and 7.4% (3.8-11.0%), respectively. IgM were more frequently found in males (24.3%), and in individuals aged 20-29 (25.9%) and 60-69 (30.4%) years. No relationship was found between exposure to COVID-19 patients and IgM and IgG positivity. The present study did show a low prevalence of SARS-CoV-2 IgM in Italian HCWs. New studies are needed to assess the prevalence of SARS-CoV-2 antibodies in HCWs exposed to COVID-19 patients, as well the role of neutralizing antibodies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-2466eISSN: 1471-2466DOI: 10.1186/s12890-020-01237-0Titel-ID: cdi_doaj_primary_oai_doaj_org_article_fc6e072823fd4431b23bc4ba62cbcb1b
- Format
- –
- Schlagworte
- Adult, Age, Age Factors, Aged, Antibodies, Antibodies, Viral - analysis, Antibodies, Viral - classification, Betacoronavirus - immunology, Betacoronavirus - isolation & purification, Clinical Laboratory Techniques - methods, Clinical Laboratory Techniques - statistics & numerical data, Coronavirus Infections - diagnosis, Coronavirus Infections - epidemiology, Coronavirus Infections - immunology, Coronaviruses, COVID-19, COVID-19 Testing, Demographic aspects, Disease transmission, Epidemics, Female, HCWs, Health aspects, Health Personnel - statistics & numerical data, Hospitals, Humans, Immunoglobulin G, Immunoglobulin M, Immunology, Immunopathogenesis, Infections, Infectious Disease Transmission, Patient-to-Professional - prevention & control, Infectious Disease Transmission, Patient-to-Professional - statistics & numerical data, Infectious diseases, Italy, Italy - epidemiology, Male, Males, Medical personnel, Middle Aged, Occupational Exposure - statistics & numerical data, Pandemics, Physicians, Pneumonia, Viral - diagnosis, Pneumonia, Viral - epidemiology, Pneumonia, Viral - immunology, Public health, Pulmonology, Quality control, Risk factors, SARS-CoV-2, Seroepidemiologic Studies, Serology, Seroprevalence, Severe acute respiratory syndrome coronavirus 2, Sex Factors, Statistics, Variables, Viruses