Details

Autor(en) / Beteiligte

• Martinez-Lozada, Zila
• Hewett, Sandra J.
• Zafra, Francisco
• Ortega, Arturo

Titel

Editorial: The known, the unknown, and the future of glutamate transporters

Ist Teil von

• Frontiers in cellular neuroscience, 2022-08, Vol.16, p.1005834-1005834

Ort / Verlag

Lausanne: Frontiers Research Foundation

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• [...]maintenance of the glutamate extracellular concentration involves tight control of its release and uptake. [...]the cystine/glutamate exchanger, also known as system x−c xc− , exports glutamate in exchange for cystine (Jabaudon et al., 1999; Warr et al., 1999; Featherstone and Shippy, 2008). Abnormalities in uptake and motor function were alleviated via over-expression of a C-terminal truncated EAAT2 protein (Hirschberg et al.). Because most of the glutamate clearance (80–90%) is mediated by astrocytic EAAT2/GLT-1, the function of GLT-1 in other cell types has remained largely unexplored. [...]the Robinson group used pharmacological inhibition of EAAT function to demonstrate their importance to arteriole patency (Jackson et al.), highlighting another important function of EAATs, which is to act as a bridge between local neuronal activity and increases in blood flow.