Details

Autor(en) / Beteiligte

• Cao, Duc Danh
• Trinh, Thi Thanh Van
• Mai, Huong Doan Thi
• Vu, Van Nam
• Le, Hong Minh
• Thi, Quyen Vu
• Nguyen, Mai Anh
• Duong, Thu Trang
• Tran, Dang Thach
• Chau, Van Minh
• Ma, Rui
• Shetye, Gauri
• Cho, Sanghyun
• Murphy, Brian T
• Pham, Van Cuong

Titel

Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea

Ist Teil von

• Marine drugs, 2019-09, Vol.17 (9), p.529

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Three new lavandulylated flavonoids, (2 ,2'' )-6-lavandulyl-7,4'-dimethoxy-5,2'-dihydroxylflavanone ( ), (2 ,2'' )-6-lavandulyl-5,7,2',4'-tetrahydroxylflavanone ( ), and (2'' )-5'-lavandulyl-2'-methoxy-2,4,4',6'-tetrahydroxylchalcone ( ), along with seven known compounds were isolated from culture broth of s sp. G248. Their structures were established by spectroscopic data analysis, including 1D and 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The absolute configurations of were resolved by comparison of their experimental and calculated electronic circular dichroism spectra. Compounds exhibited remarkable antimicrobial activity. Whereas, two known compounds and exhibited inhibitory activity against H37Rv with minimum inhibitory concentration (MIC) values of 6.0 µg/mL and 11.1 µg/mL, respectively.