Details

Autor(en) / Beteiligte

• Heller, Sandra
• Melzer, Michael Karl
• Azoitei, Ninel
• Julier, Cécile
• Kleger, Alexander

Titel

Human Pluripotent Stem Cells Go Diabetic: A Glimpse on Monogenic Variants

Ist Teil von

• Frontiers in endocrinology (Lausanne), 2021-05, Vol.12, p.648284

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2021

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Diabetes, as one of the major diseases in industrial countries, affects over 350 million people worldwide. Type 1 (T1D) and type 2 diabetes (T2D) are the most common forms with both types having invariable genetic influence. It is accepted that a subset of all diabetes patients, generally estimated to account for 1-2% of all diabetic cases, is attributed to mutations in single genes. As only a subset of these genes has been identified and fully characterized, there is a dramatic need to understand the pathophysiological impact of genetic determinants on -cell function and pancreatic development but also on cell replacement therapies. Pluripotent stem cells differentiated along the pancreatic lineage provide a valuable research platform to study such genes. This review summarizes current perspectives in applying this platform to study monogenic diabetes variants.