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Helicobacter pylori Eradication Therapy Affect the Gut Microbiota and Ghrelin Levels
Ist Teil von
Frontiers in medicine, 2021-08, Vol.8, p.712908-712908
Ort / Verlag
Frontiers Media S.A
Erscheinungsjahr
2021
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Background:
Antibiotic therapy used to eradicate
Helicobacter pylori
has been associated with changes in plasma ghrelin and alterations in the gut microbiota. On the other hand, changes in ghrelin levels have been related to changes in gut microbiota composition. Our aim was to evaluate the relationship between changes in the gut microbiota and ghrelin levels in
H. pylori
infected patients who received antibiotic treatment for its eradication.
Methods:
A prospective case-control study that included forty
H. pylori
-positive patients who received eradication therapy (omeprazole, clarithromycin, and amoxicillin) and twenty healthy
H. pylori
antigen-negative participants. Patients were evaluated, including clinical, anthropometric and dietary variables, before and 2 months after treatment. Gut microbiota composition was analyzed through 16S rRNA amplicon sequencing (IlluminaMiSeq).
Results:
Changes in gut microbiota profiles and decrease in ghrelin levels were identified after
H. pylori
eradication treatment. Gut bacteria such as
Bifidobacterium longum, Bacteroides, Prevotella, Parabacteroides distasonis
, and
RS045
have been linked to ghrelin levels fasting and/or post meals. Changes in the abundance of
Lachnospiraceae
, its genus
Blautia
, as well as
Prevotella stercorea
, and
Megasphaera
have been inversely associated with changes in ghrelin after eradication treatment.
Conclusions:
Eradication treatment for
H. pylori
produces changes in the composition of the intestinal microbiota and ghrelin levels. The imbalance between lactate producers such as
Blautia
, and lactate consumers such as
Megasphaera, Lachnospiraceae
, or
Prevotella
, could trigger changes related to ghrelin levels under the alteration of the eradication therapy used for
H. pylori
. In addition, acetate producing bacteria such as
B. longum, Bacteroides
, and
P. distasonis
could also play an important role in ghrelin regulation.