Details

Autor(en) / Beteiligte

• Mandala, Evdokia
• Lafara, Kyranna
• Kokkinovasilis, Dimitrios
• Kalafatis, Ioannis
• Koukoulitsa, Vasiliki
• Katodritou, Eirini
• Lafaras, Christos

Titel

Applied Cardio-Oncology in Hematological Malignancies: A Narrative Review

Ist Teil von

• Life (Basel, Switzerland), 2024-04, Vol.14 (4), p.524

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2024

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Applied cardio-oncology in hematological malignancies refers to the integration of cardiovascular care and management for patients with blood cancer, particularly leukemia, lymphoma, and multiple myeloma. Hematological cancer therapy-related cardiotoxicity deals with the most common cardiovascular complications of conventional chemotherapy, targeted therapy, immunotherapy, chimeric antigen receptor T (CAR-T) cell and tumor-infiltrating lymphocyte therapies, bispecific antibodies, and hematopoietic stem cell transplantation. This narrative review focuses on hematological cancer-therapy-related cardiotoxicity's definition, risk stratification, multimodality imaging, and use of cardiac biomarkers to detect clinical and/or subclinical myocardial dysfunction and electrical instability. Moreover, the most common cardiotoxic profiles of the main drugs and/or therapeutic interventions in patients with hematological malignancies are described thoroughly.