Details

Autor(en) / Beteiligte

• Guo, Bei-Cyuan
• Wu, Kang-Hsi
• Chen, Chun-Yu
• Lin, Wen-Ya
• Chang, Yu-Jun
• Lee, Tai-An
• Lin, Mao-Jen
• Wu, Han-Ping

Titel

Mesenchymal Stem Cells in the Treatment of COVID-19

Ist Teil von

• International journal of molecular sciences, 2023-10, Vol.24 (19), p.14800

Ort / Verlag

Basel: MDPI AG

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Since the emergence of the coronavirus disease 2019 (COVID-19) pandemic, many lives have been tragically lost to severe infections. The COVID-19 impact extends beyond the respiratory system, affecting various organs and functions. In severe cases, it can progress to acute respiratory distress syndrome (ARDS) and multi-organ failure, often fueled by an excessive immune response known as a cytokine storm. Mesenchymal stem cells (MSCs) have considerable potential because they can mitigate inflammation, modulate immune responses, and promote tissue regeneration. Accumulating evidence underscores the efficacy and safety of MSCs in treating severe COVID-19 and ARDS. Nonetheless, critical aspects, such as optimal routes of MSC administration, appropriate dosage, treatment intervals, management of extrapulmonary complications, and potential pediatric applications, warrant further exploration. These research avenues hold promise for enriching our understanding and refining the application of MSCs in confronting the multifaceted challenges posed by COVID-19.