Toxins, 2019-02, Vol.11 (2), p.89
2019
Details
- Autor(en) / Beteiligte
- Titel
- A Novel Phospholipase A2 Isolated from Palythoa caribaeorum Possesses Neurotoxic Activity
- Ist Teil von
- Toxins, 2019-02, Vol.11 (2), p.89
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Zoanthids of the genus are distributed worldwide in shallow waters around coral reefs. Like all cnidarians, they possess nematocysts that contain a large diversity of toxins that paralyze their prey. This work was aimed at isolating and functionally characterizing a cnidarian neurotoxic phospholipase named A2-PLTX-Pcb1a for the first time. This phospholipase was isolated from the venomous extract of the zoanthid . This enzyme, which is Ca -dependent, is a 149 amino acid residue protein. The analysis of the A2-PLTX-Pcb1a sequence showed neurotoxic domain similitude with other neurotoxic sPLA₂´s, but a different catalytic histidine domain. This is remarkable, since A2-PLTX-Pcb1a displays properties like those of other known PLA₂ enzymes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2072-6651eISSN: 2072-6651DOI: 10.3390/toxins11020089Titel-ID: cdi_doaj_primary_oai_doaj_org_article_f98bad80da0244a19fb480856a07844a
- Format
- –
- Schlagworte
- Amino acid sequence, Amino acids, Animals, Anthozoa, Behavior, Animal - drug effects, Binding sites, Calcium, Calcium ions, cnidaria, Coral reefs, Domains, Enzymes, Histidine, Injections, Intraventricular, Male, Motor Activity - drug effects, Motor Cortex - drug effects, Motor Cortex - pathology, Nematocysts, Neurotoxicity, Neurotoxicity Syndromes, neurotoxin, Neurotoxins - chemistry, Neurotoxins - isolation & purification, Neurotoxins - toxicity, Palythoa caribaeorum, Peptides, Phospholipase, Phospholipase A2, Phospholipases A2 - chemistry, Phospholipases A2 - isolation & purification, Phospholipases A2 - toxicity, Prey, Rats, Wistar, Shallow water, Toxins, Venom