Details

Autor(en) / Beteiligte

• Shi, Pengzhi
• Cheng, Zhangrong
• Zhao, Kangcheng
• Chen, Yuhang
• Zhang, Anran
• Gan, Weikang
• Zhang, Yukun

Titel

Active targeting schemes for nano-drug delivery systems in osteosarcoma therapeutics

Ist Teil von

• Journal of nanobiotechnology, 2023-03, Vol.21 (1), p.103-103, Article 103

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2023

Quelle

SpringerLink

Beschreibungen/Notizen

• Osteosarcoma, the most common malignant tumor of the bone, seriously influences people's lives and increases their economic burden. Conventional chemotherapy drugs achieve limited therapeutic effects owing to poor targeting and severe systemic toxicity. Nanocarrier-based drug delivery systems can significantly enhance the utilization efficiency of chemotherapeutic drugs through targeting ligand modifications and reduce the occurrence of systemic adverse effects. A variety of ligand-modified nano-drug delivery systems have been developed for different targeting schemes. Here we review the biological characteristics and the main challenges of current drug therapy of OS, and further elaborate on different targeting schemes and ligand selection for nano-drug delivery systems of osteosarcoma, which may provide new horizons for the development of advanced targeted drug delivery systems in the future.