Details

Autor(en) / Beteiligte

• Hung, Hao-Chien
• Hsu, Po-Jung
• Chang, Ting-Chang
• Chou, Hung-Hsueh
• Huang, Kuan-Gen
• Lai, Chyong-Huey
• Lee, Chao-Wei
• Yu, Ming-Chin
• You, Jeng-Fu
• Hsu, Yu-Jen
• Hsu, Jun-Te
• Wu, Ting-Jung

Titel

The Impact of Multidisciplinary Team Approach on Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis

Ist Teil von

• Journal of personalized medicine, 2021-12, Vol.11 (12), p.1313

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2021

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a therapeutic approach used to achieve curative treatment in intra-abdominal malignancy with peritoneal carcinomatosis (PC). However, it is a complicated procedure with high post-operative complication rates. Thus, we analyzed our preliminary data to establish whether multidisciplinary teamwork (MDT) implementation is beneficial for CRS-HIPEC outcomes. A series of 132 consecutive patients with synchronous or recurrent PC secondary to gastrointestinal or gynecologic cancer who received CRS-HIPEC operation between May 2015 and September 2017 were included. Ninety-nine patients were categorized into the MDT group, with the 33 other patients into the non-MDT group. The mean PCI score was 16.3 ± 8.8. Patients in the MDT group more often presented a higher PCI score ( value = 0.038). Regarding CRS completeness (CCR 0-1), it was distributed 81.8% and 57.6% in the MDT and the non-MDT group, respectively ( value = 0.005). Although post-operative complications were common ( = 62, 47.0%), post-operative complication rates did not differ between the two groups. The cumulative OS survival rate at the first year was 75.5%. Older age ( = 0.030, HR = 4.58, 95% CI = 1.16-18.10), ECOG 2 ( = 0.030, HR = 6.41, 95% CI = 1.20-34.14), and incomplete cytoreduction ( = 0.048, HR = 2.79, 95% CI = 1.04-8.27) were independent prognostic factors for survival. Our experience suggests that the CRS-HIPEC performed under MDT cooperation may result in higher complete cytoreduction rates without increasing post-operative complications and hospital mortalities.