Details

Autor(en) / Beteiligte

• Kaczmarek, Radoslaw
• Zimmer, Katarzyna
• Gajdzis, Pawel
• Gajdzis, Malgorzata

Titel

The Role of Eph Receptors and Ephrins in Corneal Physiology and Diseases

Ist Teil von

• International journal of molecular sciences, 2021-04, Vol.22 (9), p.4567

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2021

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The cornea, while appearing to be simple tissue, is actually an extremely complex structure. In order for it to retain its biomechanical and optical properties, perfect organization of its cells is essential. Proper regeneration is especially important after injuries and in the course of various diseases. Eph receptors and ephrin are mainly responsible for the proper organization of tissues as well as cell migration and communication. In this review, we present the current state of knowledge on the role of Eph and ephrins in corneal physiology and diseases, in particular, we focused on the functions of the epithelium and endothelium. Since the role of Eph and ephrins in the angiogenesis process has been well established, we also analyzed their influence on conditions with corneal neovascularization.