Cells (Basel, Switzerland), 2021-11, Vol.10 (11), p.3000
2021
Details
- Autor(en) / Beteiligte
- Titel
- Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis
- Ist Teil von
- Cells (Basel, Switzerland), 2021-11, Vol.10 (11), p.3000
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- EZB Free E-Journals
- Beschreibungen/Notizen
- Interleukin (IL)-4 and IL-13 belong to the T helper 2 (Th2) cytokine family, along with IL-3, IL-5, and IL-9. These cytokines are key mediators of allergic inflammation. They have important immunomodulatory activities and exert influence on a wide variety of immune cells, such as B cells, eosinophils, basophils, monocytes, fibroblasts, endothelial cells, airway epithelial cells, smooth muscle cells, and keratinocytes. Recent studies have implicated IL-4 and IL-13 in the development of various autoimmune diseases. Additionally, these cytokines have emerged as potential players in pathogenesis of inflammatory arthritis. Recent findings suggest that the IL-4 and IL-13 might play a significant role in the downregulation of inflammatory processes underlying RA pathology, and beneficially modulate the course of the disease. This review summarizes the biological features of the IL-4 and IL-13 and provides current knowledge regarding the role of these cytokines in inflammatory arthritis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2073-4409eISSN: 2073-4409DOI: 10.3390/cells10113000Titel-ID: cdi_doaj_primary_oai_doaj_org_article_f7c96085f4b24883a7582911cb09fe8b
- Format
- –
- Schlagworte
- Amino acids, Animals, ankylosing spondylitis, Antigens, Arthritis, Arthritis - blood, Arthritis - complications, Arthritis - genetics, Arthritis - metabolism, Autoimmune diseases, Bone and Bones - metabolism, Cytokines, Disease, Disease Models, Animal, Endothelial cells, Epithelial cells, Fibroblasts, Gene expression, Humans, Hypersensitivity, IL-4, Immunomodulation, Inflammation, Inflammation - blood, Inflammation - complications, Inflammation - genetics, Inflammation - metabolism, inflammatory arthritis, Interleukin 13, Interleukin 3, Interleukin 4, Interleukin 5, Interleukin 9, Interleukin-13 - blood, Interleukin-13 - genetics, Interleukin-13 - metabolism, Interleukin-4 - blood, Interleukin-4 - genetics, Interleukin-4 - metabolism, Keratinocytes, Kinases, Leukocytes (basophilic), Leukocytes (eosinophilic), Lymphocytes B, Lymphocytes T, Monocytes, Pathogenesis, Peptides, Phosphorylation, Polymorphism, Proteins, Psoriasis, psoriatic arthritis, Review, rheumatoid arthritis, Smooth muscle, spondyloarthritis, Transcription factors