Details

Autor(en) / Beteiligte

• Barilar, Ivan
• Battaglia, Simone
• Borroni, Emanuele
• Brandao, Angela Pires
• Brankin, Alice
• Carter, Joshua
• Claxton, Pauline
• Clifton, David A.
• Cohen, Ted
• Coronel, Jorge
• Crook, Derrick W.
• Dreyer, Viola
• Earle, Sarah G.
• Escuyer, Vincent
• Ferrazoli, Lucilaine
• Fowler, Philip W.
• Gao, George Fu
• Gardy, Jennifer
• Ghisi, Kelen Teixeira
• Ghodousi, Arash
• Gibertoni Cruz, Ana Luíza
• Grazian, Clara
• Guthrie, Jennifer L.
• Hoffmann, Harald
• Hoosdally, Sarah J.
• Hunt, Martin
• Iqbal, Zamin
• Ismail, Nazir Ahmed
• Jarrett, Lisa
• Joseph, Lavania
• Kambli, Priti
• Khot, Rukhsar
• Knaggs, Jeff
• Koch, Anastasia
• Kohlerschmidt, Donna
• Kouchaki, Samaneh
• Lachapelle, Alexander S.
• Lalvani, Ajit
• Lapierre, Simon Grandjean
• Laurenson, Ian F.
• Letcher, Brice
• Lin, Wan-Hsuan
• Liu, Chunfa
• Liu, Dongxin
• Malone, Kerri M.
• Mansjö, Mikael
• de Freitas Mendes, Flávia
• Merker, Matthias
• Mihalic, Marina
• Millard, James
• Miotto, Paolo
• Mistry, Nerges
• Moore, David
• Musser, Kimberlee A.
• Ngcamu, Dumisani
• Nhung, Hoang Ngoc
• Niemann, Stefan
• Nilgiriwala, Kayzad Soli
• Okozi, Nana
• Oliveira, Rosangela Siqueira
• Omar, Shaheed Vally
• Paton, Nicholas
• Peto, Timothy E. A.
• Pinhata, Juliana Maira Watanabe
• Plesnik, Sara
• Puyen, Zully M.
• Rabodoarivelo, Marie Sylvianne
• Rakotosamimanana, Niaina
• Rancoita, Paola M. V.
• Rathod, Priti
• Robinson, Esther Rhiannon
• Rodger, Gillian
• Rodrigues, Camilla
• Roohi, Aysha
• Shah, Sanchi
• Smith, Grace
• Kohl, Thomas Andreas
• Solano, Walter
• Steyn, Adrie J. C.
• Supply, Philip
• Surve, Utkarsha
• Tahseen, Sabira
• Thuong, Nguyen Thuy Thuong
• Thwaites, Guy
• Trovato, Alberto
• Utpatel, Christian
• Van Rie, Annelies
• Vijay, Srinivasan
• Walker, A. Sarah
• Walker, Timothy M.
• Warren, Robin
• Werngren, Jim
• Wijkander, Maria
• Wilson, Daniel J.
• Wintringer, Penelope
• Xiao, Yu-Xin
• Yang, Yang
• Yanlin, Zhao
• Yao, Shen-Yuan
• Zhu, Baoli

Titel

Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach

Ist Teil von

• Nature communications, 2024-01, Vol.15 (1), p.488-488, Article 488

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2024

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• The World Health Organization has a goal of universal drug susceptibility testing for patients with tuberculosis. However, molecular diagnostics to date have focused largely on first-line drugs and predicting susceptibilities in a binary manner (classifying strains as either susceptible or resistant). Here, we used a multivariable linear mixed model alongside whole genome sequencing and a quantitative microtiter plate assay to relate genomic mutations to minimum inhibitory concentration (MIC) in 15,211 Mycobacterium tuberculosis clinical isolates from 23 countries across five continents. We identified 492 unique MIC-elevating variants across 13 drugs, as well as 91 mutations likely linked to hypersensitivity. Our results advance genetics-based diagnostics for tuberculosis and serve as a curated training/testing dataset for development of drug resistance prediction algorithms.