Details

Autor(en) / Beteiligte

• Jin, Hangbiao
• Lin, Shu
• Dai, Wei
• Feng, Lingfang
• Li, Tao
• Lou, Jianlin
• Zhang, Quan

Titel

Exposure sources of perfluoroalkyl acids and influence of age and gender on concentrations of chlorinated polyfluorinated ether sulfonates in human serum from China

Ist Teil von

• Environment international, 2020-05, Vol.138, p.105651, Article 105651

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2020

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• [Display omitted] •PFCAs and PFSAs in human serum were mainly from direct exposure.•The mean 6:2Cl-PFAES serum concentration was higher than PFOA.•6:2Cl-PFAES concentrations in male serum significantly increased with age.•6:2Cl-PFAES concentrations were positively correlated with PFOS in human serum. The presence of perfluoroalkyl acids (PFAAs) and chlorinated polyfluoroalkyl ether sulfonates (Cl-PFAESs) in humans has attracted great attention in recent decades. However, information on their exposure sources and the influence of age and gender on Cl-PFAES concentrations in human serum is still limited. In this study, eighty-five serum samples were collected from the general population in Anji, China, and analyzed for perfluoroalkyl carboxylates (PFCAs), perfluoroalkyl sulfonates (PFSAs), and Cl-PFAESs. Perfluorooctane sulfonate (PFOS; mean, 5.9 ng/mL) and perfluorooctanoate (PFOA; 3.3 ng/mL) were the predominant PFAAs in human serum. The serum concentrations of C8–C12 PFCAs, perfluorohexane sulfonate, and PFOS were significantly (rs = 0.40–0.98, p < 0.01) correlated with one another. In human serum, the mean percentages of branched isomers for PFOA, perfluorohexane sulfonate, and PFOS were 97.3%, 92.6%, and 66%, respectively. These results suggest that the major source of PFCAs and PFSAs in human serum was direct exposure. The mean 6:2Cl-PFAES (6.0 ng/mL) serum concentration was higher than PFOA (p < 0.01). The mean 6:2Cl-PFAES concentrations in male and female serum were 6.5 ng/mL and 5.6 ng/mL, respectively. A significant increase in 6:2Cl-PFAES concentrations with age was found in males (rs = 0.50, p = 0.001). The 6:2Cl-PFAES concentration was positively correlated with C8–C12 PFCAs and PFOS in human serum (rs = 0.44–0.91, p < 0.01), indicating that they may have common exposure sources. Overall, this study first investigated the roles of age and gender on human serum concentrations of Cl-PFAESs and provided baseline information on the occurrence of Cl-PFAESs in the general Chinese population.