Details

Autor(en) / Beteiligte

• Li, Wenlu
• Mandeville, Emiri T
• Durán-Laforet, Violeta
• Fukuda, Norito
• Yu, Zhanyang
• Zheng, Yi
• Held, Aaron
• Park, Ji-Hyun
• Nakano, Takafumi
• Tanaka, Masayoshi
• Shi, Jingfei
• Esposito, Elga
• Niu, Wanting
• Xing, Changhong
• Hayakawa, Kazuhide
• Lizasoain, Ignacio
• van Leyen, Klaus
• Ji, Xunming
• Wainger, Brian J
• Moro, Maria A
• Lo, Eng H

Titel

Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke

Ist Teil von

• Nature communications, 2022-12, Vol.13 (1), p.7812-7812, Article 7812

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for example, brain endothelial cells play a key role by supplying trophic support to neural progenitors. Here, we describe a surprising phenomenon where brain endothelial cells may release trans-differentiation signals that convert astrocytes into neural progenitor cells in male mice after stroke. After oxygen-glucose deprivation, brain endothelial cells release microvesicles containing pro-neural factor Ascl1 that enter into astrocytes to induce their trans-differentiation into neural progenitors. In mouse models of focal cerebral ischemia, Ascl1 is upregulated in endothelium prior to astrocytic conversion into neural progenitor cells. Injecting brain endothelial-derived microvesicles amplifies the process of astrocyte trans-differentiation. Endothelial-specific overexpression of Ascl1 increases the local conversion of astrocytes into neural progenitors and improves behavioral recovery. Our findings describe an unexpected vascular-regulated mechanism of neuroplasticity that may open up therapeutic opportunities for improving outcomes after stroke.