Details

Autor(en) / Beteiligte

• Quarcoo, David
• Fischer, Tanja C
• Peckenschneider, Nora
• Groneberg, David A
• Welker, Pia

Titel

High abundances of neurotrophin 3 in atopic dermatitis mast cell

Ist Teil von

• Journal of occupational medicine and toxicology (London, England), 2009-04, Vol.4 (1), p.8-8

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2009

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Neurotrophin 3 (NT-3) is a member of the neurotrophin family, a group of related proteins that are known to regulate neuro-immune interactions in allergic diseases. Their cellular sources and role in the recruitment of mast cell precursors in atopic dermatitis have not been characterized in detail so far. Characterize NT-3 on a transcriptional and translational level in individuals with atopic dermatitis with special focus on mast cells. To meet this objective NT-3 levels in the serum of AD patients were measured, the effect of NT-3 on keratinocytes was evaluated and the gene expression and regulation assessed using ELISA, immunohistochemistry and RNA quantification. Systemic levels of NT-3 were found to be higher in individuals with AD as compared to healthy controls. A distinct genetic expression was found in the various cells of the skin. In lesional mast cells of individuals with atopic dermatitis an increased amount of NT-3 was apparent. Functional in vitro experiments demonstrated that NT-3 stimulation led to a suppression of IL-8 secretion by HaCat cells. These findings could imply a role for NT-3 in the pathogenesis of allergic skin diseases.