Details

Autor(en) / Beteiligte

• Nicolas, Camille
• Petit, Claire
• Tallet, Agnès
• Boher, Jean-Marie
• Varela Cagetti, Leonel
• Favrel, Veronique
• Gonzague Casabianca, Laurence
• Guenole, Morgan
• Mailleux, Hugues
• Darreon, Julien
• Bannier, Marie
• Cohen, Monique
• Sabiani, Laura
• Tallet, Camille
• Teyssandier, Charlene
• Gonçalves, Anthony
• De Nonneville, Alexandre
• Lopez Almeida, Leonor
• Coste, Nathan
• Tyran, Marguerite
• Houvenaeghel, Gilles

Titel

Does Breast Surgery Type Alter Incidental Axillary Irradiation? A Dosimetric Analysis of the "Sentinel Envahi et Randomisation du Curage" SERC Trial

Ist Teil von

• Cancers, 2024-03, Vol.16 (6), p.1198

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2024

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• An incidental axillary dose of adjuvant radiotherapy using tangential beams is usually given after breast-conserving surgery for breast cancer. The goal of this sub-study was to evaluate this incidental dose in the setting of post-mastectomy radiotherapy (PMRT) according to two different radiotherapy techniques. Patients participating in a randomized SERC trial who received PMRT in a single center were included. We collected the incidental axillary dose delivered to the Berg level 1 using different dosimetric parameters and compared two techniques using Student's -test: three-dimensional conformal radiotherapy (3D-CRT) and volumetric arc therapy (VMAT). We analyzed radiotherapy plans from 52 patients who received PMRT from 2012 to 2021. The mean dose delivered to the Berg level 1 was 37.2 Gy. It was significantly higher with VMAT than with 3D-CRT-43.6 Gy (SD = 3.1 Gy) versus 34.8 Gy (SD = 8.6 Gy) < 0.001. Eighty-four percent of the Berg level 1 was covered by 40 Gy isodose in the VMAT group versus 55.5% in the 3D-CRT group < 0.001. On the Berg level 1, PMRT gives a dose at least equivalent to the one given by post-breast-conserving surgery radiotherapy, making it possible to limit completion axillary lymph node dissections in select pN1a patients treated with a mastectomy. Modern radiotherapy techniques like VMAT tend to increase this incidental dose.