Details

Autor(en) / Beteiligte

• Safak, Okan
• Wang, Shenghan
• Mota Reyes, Carmen
• Gürcinar, Ibrahim Halil
• Tokalov, Sergey
• Cevik, Nedim Can
• Görgülü, Kivanc
• Yilmaz, Bengi Su
• Erdogan, Emre
• Ye, Linhan
• Li, Qiaolin
• Sever, Elif Arik
• Özer, Samed
• Süyen, Güldal
• Friess, Helmut
• Ceyhan, Güralp Onur
• Istvanffy, Rouzanna
• Algül, Hana
• Demir, Ihsan Ekin

Titel

Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

Ist Teil von

• Cancer communications (London, England), 2024-01, Vol.44 (1), p.178-182

Ort / Verlag

United States: John Wiley & Sons, Inc

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• [...]selective blocking of these receptors can change the immune cell distribution towards CD8+ immune-competent cell lines. [...]we interbred compound KC mouse mutants with IL-6 knockout allele (Il-6−/−) or the conditional Cxcl12lox/+ allele and analyzed the distribution of immune cells in the pancreas (Supplementary Figure S8A-C). [...]the CD8+:CD11b+ ratio was significantly higher in mice with cytokine depletion (KC vs. [...]the treated animals showed a higher mean 13-week survival rate (Control vs. [...]we showed that autochthonous, oncogenic Kras-based mouse models of PDAC have a specific immune cell distribution in the primary tumor, comparable to human PDAC at only few time points of tumor development.