Details

Autor(en) / Beteiligte

• Groblewski, Peter A
• Ollerenshaw, Douglas R
• Kiggins, Justin T
• Garrett, Marina E
• Mochizuki, Chris
• Casal, Linzy
• Cross, Sissy
• Mace, Kyla
• Swapp, Jackie
• Manavi, Sahar
• Williams, Derric
• Mihalas, Stefan
• Olsen, Shawn R

Titel

Characterization of Learning, Motivation, and Visual Perception in Five Transgenic Mouse Lines Expressing GCaMP in Distinct Cell Populations

Ist Teil von

• Frontiers in behavioral neuroscience, 2020-06, Vol.14, p.104-104

Ort / Verlag

Switzerland: Frontiers Research Foundation

Erscheinungsjahr

2020

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• To study the mechanisms of perception and cognition, neural measurements must be made during behavior. A goal of the is to map the activity of distinct cortical cell classes underlying visual and behavioral processing. Here we describe standardized methodology for training head-fixed mice on a visual change detection task, and we use our paradigm to characterize learning and behavior of five GCaMP6-expressing transgenic lines. We used automated training procedures to facilitate comparisons across mice. Training times varied, but most transgenic mice learned the behavioral task. Motivation levels also varied across mice. To compare mice in similar motivational states we subdivided sessions into over-, under-, and optimally motivated periods. When motivated, the pattern of perceptual decisions were highly correlated across transgenic lines, although overall performance (d-prime) was lower in one line labeling somatostatin inhibitory cells. These results provide important context for using these mice to map neural activity underlying perception and behavior.