Details

Autor(en) / Beteiligte

• Legebeke, Jelmer
• Lord, Jenny
• Penrice-Randal, Rebekah
• Vallejo, Andres F
• Poole, Stephen
• Brendish, Nathan J
• Dong, Xiaofeng
• Hartley, Catherine
• Holloway, John W
• Lucas, Jane S
• Williams, Anthony P
• Wheway, Gabrielle
• Strazzeri, Fabio
• Gardner, Aaron
• Schofield, James P R
• Skipp, Paul J
• Hiscox, Julian A
• Polak, Marta E
• Clark, Tristan W
• Baralle, Diana

Titel

Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19

Ist Teil von

• Frontiers in immunology, 2022-05, Vol.13, p.853265-853265

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The worldwide COVID-19 pandemic has claimed millions of lives and has had a profound effect on global life. Understanding the body's immune response to SARS-CoV-2 infection is crucial in improving patient management and prognosis. In this study we compared influenza and SARS-CoV-2 infected patient cohorts to identify distinct blood transcript abundances and cellular composition to better understand the natural immune response associated with COVID-19, compared to another viral infection being influenza, and identify a prognostic signature of COVID-19 patient outcome. Clinical characteristics and peripheral blood were acquired upon hospital admission from two well characterised cohorts, a cohort of 88 patients infected with influenza and a cohort of 80 patients infected with SARS-CoV-2 during the first wave of the pandemic and prior to availability of COVID-19 treatments and vaccines. Gene transcript abundances, enriched pathways and cellular composition were compared between cohorts using RNA-seq. A genetic signature between COVID-19 survivors and non-survivors was assessed as a prognostic predictor of COVID-19 outcome. Contrasting immune responses were detected with an innate response elevated in influenza and an adaptive response elevated in COVID-19. Additionally ribosomal, mitochondrial oxidative stress and interferon signalling pathways differentiated the cohorts. An adaptive immune response was associated with COVID-19 survival, while an inflammatory response predicted death. A prognostic transcript signature, associated with circulating immunoglobulins, nucleosome assembly, cytokine production and T cell activation, was able to stratify COVID-19 patients likely to survive or die. This study provides a unique insight into the immune responses of treatment naïve patients with influenza or COVID-19. The comparison of immune response between COVID-19 survivors and non-survivors enables prognostication of COVID-19 patients and may suggest potential therapeutic strategies to improve survival.