Details

Autor(en) / Beteiligte

• Agrati, Chiara
• Capone, Stefania
• Castilletti, Concetta
• Cimini, Eleonora
• Matusali, Giulia
• Meschi, Silvia
• Tartaglia, Eleonora
• Camerini, Roberto
• Lanini, Simone
• Milleri, Stefano
• Colloca, Stefano
• Vitelli, Alessandra
• Folgori, Antonella

Titel

Strong immunogenicity of heterologous prime-boost immunizations with the experimental vaccine GRAd-COV2 and BNT162b2 or ChAdOx1-nCOV19

Ist Teil von

• npj vaccines, 2021-11, Vol.6 (1), p.131-131, Article 131

Ort / Verlag

London: Nature Publishing Group

Erscheinungsjahr

2021

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Abstract Here we report on the humoral and cellular immune response in eight volunteers who autonomously chose to adhere to the Italian national COVID-19 vaccination campaign more than 3 months after receiving a single-administration GRAd-COV2 vaccine candidate in the context of the phase-1 clinical trial. We observed a clear boost of both binding/neutralizing antibodies as well as T-cell responses upon receipt of the heterologous BNT162b2 or ChAdOx1-nCOV19 vaccines. These results, despite the limitation of the small sample size, support the concept that a single dose of an adenoviral vaccine may represent an ideal tool to effectively prime a balanced immune response, which can be boosted to high levels by a single dose of a different vaccine platform.