Details

Autor(en) / Beteiligte

• Graham, Sophie
• Tessier, Elise
• Stowe, Julia
• Bernal, Jamie Lopez
• Parker, Edward P K
• Nitsch, Dorothea
• Miller, Elizabeth
• Andrews, Nick
• Walker, Jemma L
• McDonald, Helen I

Titel

Bias assessment of a test-negative design study of COVID-19 vaccine effectiveness used in national policymaking

Ist Teil von

• Nature communications, 2023-07, Vol.14 (1), p.3984-3984, Article 3984

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• National test-negative-case-control (TNCC) studies are used to monitor COVID-19 vaccine effectiveness in the UK. A questionnaire was sent to participants from the first published TNCC COVID-19 vaccine effectiveness study conducted by the UK Health Security Agency, to assess for potential biases and changes in behaviour related to vaccination. The original study included symptomatic adults aged ≥70 years testing for COVID-19 between 08/12/2020 and 21/02/2021. A questionnaire was sent to cases and controls tested from 1-21 February 2021. In this study, 8648 individuals responded to the questionnaire (36.5% response). Using information from the questionnaire to produce a combined estimate that accounted for all potential biases decreased the original vaccine effectiveness estimate after two doses of BNT162b2 from 88% (95% CI: 79-94%) to 85% (95% CI: 68-94%). Self-reported behaviour demonstrated minimal evidence of riskier behaviour after vaccination. These findings offer reassurance to policy makers and clinicians making decisions based on COVID-19 vaccine effectiveness TNCC studies.