Viruses, 2018-02, Vol.10 (3), p.101
2018
Details
- Autor(en) / Beteiligte
- Titel
- Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory
- Ist Teil von
- Viruses, 2018-02, Vol.10 (3), p.101
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2018
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines against these viruses. This article considers the genetic engineering of vaccinia virus (VACV) to enhance vaccine immunogenicity and safety. The virulence, immunogenicity and protective efficacy of VACV strains engineered to lack specific immunomodulatory or host range proteins are described. The ultimate goal is to develop safer and more immunogenic VACV vaccines that induce long-lasting immunological memory.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1999-4915eISSN: 1999-4915DOI: 10.3390/v10030101Titel-ID: cdi_doaj_primary_oai_doaj_org_article_f3dce02b19d049179fd7220d7a7bd0ec
- Format
- –
- Schlagworte
- Animals, Antiviral agents, Communicable Diseases, Emerging - immunology, Communicable Diseases, Emerging - metabolism, Communicable Diseases, Emerging - prevention & control, Cytokines - metabolism, Genetic Engineering, Host range, Humans, immune evasion, Immunity, Immunogenicity, Immunogenicity, Vaccine, Immunologic Memory, Immunological memory, Immunology, Immunomodulation, Inflammation Mediators - metabolism, Monkeypox, Orthopoxvirus, orthopoxviruses, Outbreaks, Review, Smallpox, Smallpox - drug therapy, Smallpox - immunology, Smallpox - metabolism, Smallpox - prevention & control, Smallpox Vaccine - immunology, vaccine, Vaccines, vaccinia virus, Vaccinia virus - genetics, Vaccinia virus - immunology, Viral Vaccines - genetics, Viral Vaccines - immunology, Virulence, Viruses, Zoonoses