Details

Autor(en) / Beteiligte

• Moreira, Thais G
• Mangani, Davide
• Cox, Laura M
• Leibowitz, Jeffrey
• Lobo, Eduardo L C
• Oliveira, Mariana A
• Gauthier, Christian D
• Nakagaki, Brenda N
• Willocq, Valerie
• Song, Anya
• Guo, Lydia
• Lima, David C A
• Murugaiyan, Gopal
• Butovsky, Oleg
• Gabriely, Galina
• Anderson, Ana C
• Rezende, Rafael M
• Faria, Ana Maria C
• Weiner, Howard L

Titel

PD-L1 + and XCR1 + dendritic cells are region-specific regulators of gut homeostasis

Ist Teil von

• Nature communications, 2021-08, Vol.12 (1), p.4907-4907, Article 4907

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The intestinal mucosa constitutes an environment of closely regulated immune cells. Dendritic cells (DC) interact with the gut microbiome and antigens and are important in maintaining gut homeostasis. Here, we investigate DC transcriptome, phenotype and function in five anatomical locations of the gut lamina propria (LP) which constitute different antigenic environments. We show that DC from distinct gut LP compartments induce distinct T cell differentiation and cytokine secretion. We also find that PD-L1 DC in the duodenal LP and XCR1 DC in the colonic LP comprise distinct tolerogenic DC subsets that are crucial for gut homeostasis. Mice lacking PD-L1 and XCR1 DC have a proinflammatory gut milieu associated with an increase in Th1/Th17 cells and a decrease in Treg cells and have exacerbated disease in the models of 5-FU-induced mucositis and DSS-induced colitis. Our findings identify PD-L1 and XCR1 DC as region-specific physiologic regulators of intestinal homeostasis.