Nature communications, 2020-07, Vol.11 (1), p.3410-3410, Article 3410
2020
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- Autor(en) / Beteiligte
- Titel
- Immunological and inflammatory profiles in mild and severe cases of COVID-19
- Ist Teil von
- Nature communications, 2020-07, Vol.11 (1), p.3410-3410, Article 3410
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2020
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cell inhibitory molecules are more prominent in severe cases than in those with mild disease. CD8+ T cells in patients with severe disease express high levels of cytotoxic molecules. Histochemical studies of lung tissue from one fatality show sub-anatomical distributions of SARS-CoV-2 RNA and massive infiltration of T cells and macrophages. Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-020-17240-2Titel-ID: cdi_doaj_primary_oai_doaj_org_article_f394b906bb734d0da841b3a0209b27e6
- Format
- –
- Schlagworte
- Adult, Aged, Aged, 80 and over, Betacoronavirus - immunology, Betacoronavirus - pathogenicity, Biomarkers - metabolism, CD4 antigen, CD4-Positive T-Lymphocytes - immunology, CD4-Positive T-Lymphocytes - pathology, CD8 antigen, CD8-Positive T-Lymphocytes - immunology, CD8-Positive T-Lymphocytes - pathology, Cell activation, Chemotaxis, Leukocyte, China - epidemiology, Coronavirus Infections - blood, Coronavirus Infections - immunology, Coronavirus Infections - pathology, Coronavirus Infections - virology, Coronaviruses, COVID-19, Cytokines - blood, Cytotoxicity, Epidemiology, Female, Humans, Immune system, Immunology, Inflammation, Killer Cells, Natural - immunology, Killer Cells, Natural - pathology, Leukocyte Count, Lung - immunology, Lung - virology, Lymphocyte Activation, Lymphocytes, Lymphocytes T, Lymphopenia, Macrophages, Male, Middle Aged, Pandemics, Pathogenesis, Patients, Pneumonia, Viral - blood, Pneumonia, Viral - immunology, Pneumonia, Viral - pathology, Pneumonia, Viral - virology, Ribonucleic acid, RNA, SARS-CoV-2, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, Therapeutic applications, Toxicity, Viral diseases