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Chaperone‐mediated autophagy affects tumor cell proliferation and cisplatin resistance in esophageal squamous cell carcinoma
Ist Teil von
Thoracic cancer, 2021-04, Vol.12 (7), p.1048-1057
Ort / Verlag
Melbourne: John Wiley & Sons Australia, Ltd
Erscheinungsjahr
2021
Quelle
Access via Wiley Online Library
Beschreibungen/Notizen
Background
Chaperone‐mediated autophagy (CMA) is a lysosomal degradation pathway of selective soluble proteins. Lysosomal membrane associated protein 2a (LAMP2a) is the lysosomal membrane receptor of CMA and influences CMA activity. Although it has been suggested that higher expression of LAMP2a is associated with more advanced tumor node metastasis (TNM) stages and shorter survival time in patients with esophageal squamous cell carcinoma (ESCC), the underlying mechanism has not been known yet.
Methods
In this study, we modulated the activity of CMA through LAMP2a or small molecular compounds in human ESCC cells to investigate its role in ESCC.
Results
We found that down‐regulating the activity of CMA could inhibit the proliferation and colony formation of ESCC cells as well as increase their sensitivity to cisplatin.
Conclusions
Our results promote better understanding of how CMA affects human ESCC and provide a new therapeutic target against ESCC through down‐regulating LAMP2a.
Inhibiting chaperone‐mediated autophagy can decrease cell growth and increase cisplatin resistance in esophageal squamous cell carcinoma.