Details

Autor(en) / Beteiligte

• Dewaeles, Edmone
• Carvalho, Kévin
• Fellah, Sandy
• Sim, Jaewon
• Boukrout, Nihad
• Caillierez, Raphaelle
• Ramakrishnan, Hariharan
• Van der Hauwaert, Cynthia
• Vijaya Shankara, Jhenkruthi
• Martin, Nathalie
• Massri, Noura
• Launay, Agathe
• Folger, Joseph K
• de Schutter, Clémentine
• Larrue, Romain
• Loison, Ingrid
• Goujon, Marine
• Jung, Matthieu
• Le Gras, Stéphanie
• Gomez-Murcia, Victoria
• Faivre, Emilie
• Lemaire, Julie
• Garat, Anne
• Beauval, Nicolas
• Maboudou, Patrice
• Gnemmi, Viviane
• Gibier, Jean-Baptiste
• Buée, Luc
• Abbadie, Corinne
• Glowacki, Francois
• Pottier, Nicolas
• Perrais, Michael
• Cunha, Rodrigo A
• Annicotte, Jean-Sébastien
• Laumet, Geoffroy
• Blum, David
• Cauffiez, Christelle

Titel

Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects

Ist Teil von

• The Journal of clinical investigation, 2022-11, Vol.132 (22), p.1-16

Ort / Verlag

United States: American Society for Clinical Investigation

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Cisplatin is a potent chemotherapeutic drug that is widely used in the treatment of various solid cancers. However, its clinical effectiveness is strongly limited by frequent severe adverse effects, in particular nephrotoxicity and chemotherapy-induced peripheral neuropathy. Thus, there is an urgent medical need to identify novel strategies that limit cisplatin-induced toxicity. In the present study, we show that the FDA-approved adenosine A2A receptor antagonist istradefylline (KW6002) protected from cisplatin-induced nephrotoxicity and neuropathic pain in mice with or without tumors. Moreover, we also demonstrate that the antitumoral properties of cisplatin were not altered by istradefylline in tumor-bearing mice and could even be potentiated. Altogether, our results support the use of istradefylline as a valuable preventive approach for the clinical management of patients undergoing cisplatin treatment.