Details

Autor(en) / Beteiligte

• Guo, Ye
• Guo, Hanfei
• Zhang, Yongfei
• Cui, Jiuwei

Titel

Anaplastic lymphoma kinase-special immunity and immunotherapy

Ist Teil von

• Frontiers in immunology, 2022-07, Vol.13, p.908894-908894

Ort / Verlag

Frontiers Media S.A

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Alterations in the anaplastic lymphoma kinase ( ALK ) gene play a key role in the development of various human tumors, and targeted therapy has transformed the treatment paradigm for these oncogene-driven tumors. However, primary or acquired resistance remains a challenge. ALK gene variants (such as gene rearrangements and mutations) also play a key role in the tumor immune microenvironment. Immunotherapy targeting the ALK gene has potential clinical applications. Here, we review the results of recent studies on the immunological relevance of ALK-altered tumors, which provides important insights into the development of tumor immunotherapies targeting this large class of tumors.