Details

Autor(en) / Beteiligte

• Li, Hao
• Xiong, Hong-Gang
• Xiao, Yao
• Yang, Qi-Chao
• Yang, Shao-Chen
• Tang, Hong-Chao
• Zhang, Wen-Feng
• Sun, Zhi-Jun

Titel

Long Non-coding RNA LINC02195 as a Regulator of MHC I Molecules and Favorable Prognostic Marker for Head and Neck Squamous Cell Carcinoma

Ist Teil von

• Frontiers in oncology, 2020-05, Vol.10, p.615-615

Ort / Verlag

Switzerland: Frontiers Research Foundation

Erscheinungsjahr

2020

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• The loss of major histocompatibility complex class I (MHC I) molecules is an important mechanism by which cancer cells escape immunosurveillance in head and neck squamous cell carcinoma (HNSCC). Several long non-coding RNAs (lncRNAs) have been implicated in immune response and regulation including antigen processing and presentation. However, few studies on lncRNAs regulating MHC I expression in HNSCC have been conducted. In this study, MHC I related lncRNAs were identified from the The Cancer Genome Atlas (TCGA) HNSCC database. One of the lncRNAs, ( ), was found to be associated with genes encoding MHC I molecules and patient prognosis in the TCGA database. KEGG and GO analyses suggested that was closely related to antigen processing and presentation. qRT-PCR revealed high expression of in human HNSCC tissues and HNSCC cell lines compared with normal mucosal tissues. hybridization of the HNSCC tissue microarray revealed a correlation between high expression and a favorable prognosis in our patient cohort. Silencing of decreased MHC I protein expression, as evidenced by western blotting. Multiplex immunochemistry was performed to reveal the positive correlation between high expression and an increased number of CD8 and CD4 T cells in the tumor microenvironment. Based on our study, is a promising prognostic marker and a target for future therapeutic interventions.