Details

Autor(en) / Beteiligte

• Kosgodage, Uchini S
• Matewele, Paul
• Awamaria, Brigitte
• Kraev, Igor
• Warde, Purva
• Mastroianni, Giulia
• Nunn, Alistair V
• Guy, Geoffrey W
• Bell, Jimmy D
• Inal, Jameel M
• Lange, Sigrun

Titel

Cannabidiol Is a Novel Modulator of Bacterial Membrane Vesicles

Ist Teil von

• Frontiers in cellular and infection microbiology, 2019-09, Vol.9, p.324

Ort / Verlag

Switzerland: Frontiers Research Foundation

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Membrane vesicles (MVs) released from bacteria participate in cell communication and host-pathogen interactions. Roles for MVs in antibiotic resistance are gaining increased attention and in this study we investigated if known anti-bacterial effects of cannabidiol (CBD), a phytocannabinoid from , could be in part attributed to effects on bacterial MV profile and MV release. We found that CBD is a strong inhibitor of MV release from Gram-negative bacteria ( VCS257), while inhibitory effect on MV release from Gram-positive bacteria ( subsp Rosenbach) was negligible. When used in combination with selected antibiotics, CBD significantly increased the bactericidal action of several antibiotics in the Gram-negative bacteria. In addition, CBD increased antibiotic effects of kanamycin in the Gram-positive bacteria, without affecting MV release. CBD furthermore changed protein profiles of MVs released from after 1 h CBD treatment. Our findings indicate that CBD may pose as a putative adjuvant agent for tailored co-application with selected antibiotics, depending on bacterial species, to increase antibiotic activity, including via MV inhibition, and help reduce antibiotic resistance.