Details

Autor(en) / Beteiligte

• Cao, Fei
• Zheng, Jiaping
• Hao, Weiyuan

Titel

Combined image-guided radiofrequency and iodine-125 seeds implantation in the treatment of recurrent hepatocellular carcinoma after hepatectomy

Ist Teil von

• BMC cancer, 2024-05, Vol.24 (1), p.666-9, Article 666

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2024

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Currently, there is no consensus on the treatment of recurrent hepatocellular carcinoma (HCC) after hepatectomy. It is necessary to assess the efficacy and safety of radiofrequency ablation (RFA) combined with iodine-125 seeds implantation (RFA- I) in the treatment of recurrent HCC. This study retrospectively analyzed the clinical data of patients with postoperative recurrence of HCC receiving RFA- I or RFA treatment from January 2013 to January 2023. Both RFA and I seeds implantation were performed under dual guidance of ultrasound and CT. Overall survival (OS), progression-free survival (PFS), recurrence, and complications were compared between the two groups. A total of 210 patients with recurrent HCC were enrolled in this study, including 125 patients in the RFA- I group and 85 patients in the RFA group. The RFA- I group showed a significantly better survival benefit than RFA group (median OS: 37 months vs. 16 months, P < 0.001; median PFS: 15 months vs. 10 months, P = 0.001). The uni- and multivariate analysis showed that RFA- I was a protective factor for OS and PFS. There were no procedure-related deaths and no grade 3 or higher adverse events in both groups. RFA combined with I seeds implantation under dual guidance of ultrasound and CT is effective and safe for the treatment of HCC patients with recurrence after hepatectomy.