Details

Autor(en) / Beteiligte

• Kim, Yoonjung
• Bae, Joon-Yong
• Kwon, Kitae
• Chang, Hyun-Ha
• Lee, Won Kee
• Park, Heedo
• Kim, Jeonghun
• Choi, Isaac
• Park, Man-Seong
• Kim, Shin-Woo

Titel

Kinetics of neutralizing antibodies against SARS-CoV-2 infection according to sex, age, and disease severity

Ist Teil von

• Scientific reports, 2022-08, Vol.12 (1), p.13491-13491, Article 13491

Ort / Verlag

London: Nature Publishing Group

Erscheinungsjahr

2022

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Abstract Knowledge of the factors affecting the difference in kinetics and longevity of the neutralizing antibody (nAb) response to SARS-CoV-2 is necessary to properly prioritize vaccination. In the present study, from March to December 2020, of the 143 patients who recovered from COVID-19, 87 underwent study visits scheduled every 3 months. Patient demographics and blood samples were collected followed by a plaque reduction neutralization test to analyze nAb titers. A linear mixed model was used to compare the effects of sex, age, and disease severity over time. Results demonstrated a gradual reduction in nAb titers over time with a significant decrease from 6 to 9 months post-COVID-19 infection ( p  < 0.001). In time-to-sex, age, and disease severity comparisons, reduction in nAb titers over time was unaffected by sex ( p  = 0.167), age ( p  = 0.188), or disease severity ( p  = 0.081). Additionally, the nAb titer was 1.46 times significantly higher in those aged ≥ 50 years than in those aged < 50 years ( p  = 0.036) irrespective of time Moreover, the nAb titer was 2.41 times higher in the moderate or above than that in the below moderate disease severity group ( p  < 0.001). However, no significant differences were observed in terms of sex ( p  = 0.300). Given the reduction in nAbs over time, maintaining protective neutralizing antibodies regardless of sex, age, or disease severity is needed.